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When sexual stimulation brings about area launch of NO, inhibition of PDE-5 by sildenafil causes elevated levels of cGMP within the corpus cavernosum, causing easy muscle rest and inflow of blood on the corpus cavernosum. Kamagra at advisable doses has no impact in the absence of sexual stimulation.
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The physiological mechanism liable for the erection on the penis entails the release of nitric oxide (NO) inside the corpus cavernosum in the course of sexual stimulation .
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In the event the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in elevated corpus cavernosum levels of cGMP . For that reason sexual stimulation is needed to ensure that sildenafil to generate its meant helpful pharmacological effects .
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